renal dosing of Trimethoprim

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Trimethoprim: Dose adjustment for renal impairment

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

Crcl (ml/min)	Dose
20 – 50	Normal
10 – 20	Use alternative agent if possible. Normal dose.
<10	Ineffective for treatment of UTI, other indications normal dose but use alternative agent if possible

Consider short term folic acid supplementation.
May cause temporary rise in creatinine due to reduced creatinine secretion rather than a fall in CrCl.

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

Page last edited: 28/04/2009

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.